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Cancer Gene Therapy​ - Gankyrin inhibitory RNA

Tenjin Cancer Clinic

gankyrin抑制RNA

The first step of cancer generation
 Genetic Abnormality

Genes in cells include "oncogenes" that produce cancer cells and "tumor suppressor genes" that suppress cancer cells that have already developed.  In the case of healthy people, a balance of division and inhibition is maintained, so cancer cells do not continue to multiply.

However, if the "tumor suppressor gene" is damaged due to diet, living environment, stress and other factors, the balance between division and inhibition is broken, and cells with abnormal genes (cancer cells) will divide endlessly.

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◎About Cancer Gene Therapy

Cancer gene therapy is a method of treating cancer by suppressing genes in the body, promoting the normalization of abnormal genes, and suitable for each patient's gene therapy.  

Cancer Treatment Without Hospitalization

 

Patients who come to the hospital regularly every 1 to 2 weeks are treated by drip, so this treatment is limited to patients who can come to the hospital regularly.

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◎The process of cancer gene therapy to eliminate cancer

​Characteristics of cancer cells: not prone to apoptosis

Induction: ​ induces apoptosis through oncogene

Cancer cell characteristics: ​ infinite proliferation

Induction: Blocks proliferative signals, inhibits cell division

Locking in cancer cell signatures

Induction: inhibition of cell proliferation through RNAi targets

◎Are there any genes that can be used in cancer gene therapy?

P53

Known as the patron saint of the genome, it is a tumor suppressor gene associated with "cancer cells". Promote apoptosis of cancerous cells.

P16

A tumor suppressor gene that delays and eliminates abnormal cell proliferation and prevents cancer.

Gankyrin inhibits RNA

Block the well-known tumor suppressor genes such as p53, p16, PTEN and RB, and target Gankyrin as the target RNA.

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CDC6 suppresses RNA

​ Inhibits cell division that allows cancer cells to proliferate, creating an environment where other tumor suppressor genes can easily act.

PTEN

Tumor suppressor gene involved in cell proliferation and abnormal proliferation of cancer cells.

TRAIL

After binding to its receptor, it initiates apoptosis signal transmission, selectively induces tumor cell apoptosis, and has no obvious damage to normal tissue cells.

◎The relationship between Gankyrin and cancer

Gankyrin gene can block famous tumor suppressor genes such as p53, p16, PTEN and RB, and is related to tumor metastasis, invasion, proliferation and cell apoptosis. At present, most cancers contain Gankyrin gene. Through the Gankyrin inhibitory RNA gene therapy conducted by Tenshin Cancer Clinic, the expression of Gankyrin gene can be inhibited, so that the tumor suppressor gene in the body can restore its original function and accelerate the disappearance of cancer cells.

◎The relationship between TRAIL and cancer

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a kind of tumor necrosis factor (tumor necrosis factor, TNF). TRAIL binds to its receptor to initiate apoptosis signal transmission, selectively induces tumor cell apoptosis, and has no obvious damage to normal tissue cells. Combining drugs and cytokines can cooperate with TRAIL to induce tumor cell apoptosis. For most malignant tumors, TRAIL can significantly inhibit tumor growth and block cancer cell metastasis.

◎Treatment process

Gankyrin inhibits RNA

One course of treatment is six times, once every three weeks.

first visit

first

the second time

the third time

​ pre-treatment check

+

​ blood test

Drip +​ blood test (confirm tumor markers)

Drip +​ blood test (confirm tumor markers)

Drip +​ blood test (confirm tumor markers)

the fourth time

​ fifth time

the sixth time

Effect detection

Drip +​ blood test (confirm tumor markers)

Drip +​ blood test (confirm tumor markers)

Drip +​ blood test (confirm tumor markers)

Confirm tumor markers

TRAIL

One course of treatment is six times, once every three weeks.

first visit

first

the second time

the third time

​ pre-treatment check

+

​ blood test

Drip +​ blood test (confirm tumor markers)

Drip +​ blood test (confirm tumor markers)

Drip +​ blood test (confirm tumor markers)

the fourth time

​ fifth time

the sixth time

Effect detection

Drip +​ blood test (confirm tumor markers)

Drip +​ blood test (confirm tumor markers)

Drip +​ blood test (confirm tumor markers)

Confirm tumor markers

◎Treatment costs​ (The following prices are in Japanese Yen)

Gankyrin gene therapy ¥/time
​A course of treatment is about ¥2,400,000(without tax)
The above fees are for reference only, and the detailed fees are subject to the provision of the hospital

*A course of treatment is six times in total, including 3 kinds of tumor suppressor genes + 2 kinds of RNAi therapeutic proteins

*Tumor suppressor gene storage fee

*Treatment technology fee

*Blood test fee

*Determination of tumor markers

TRAIL gene therapy ¥/time
​A course of treatment is about ¥2,400,000(without tax)
The above fees are for reference only, and the detailed fees are subject to the provision of the hospital

*One course of treatment is a total of six times, including (three kinds of tumor suppressor genes + RNAi therapeutic protein) X six units + TRAIL

*Tumor suppressor gene storage fee

*Treatment technology fee

*Blood test fee

*Determination of tumor markers

​◎Clinic introduction

Tenjin Cancer Clinic is a professional clinic for cancer gene therapy. In this era of increasing cancer treatment, there is no longer only the traditional treatment methods in the past. The gene therapy adopted by Tenjin Cancer Clinic is a cutting-edge medical treatment with few side effects and safety.

天神醫護人員

​◎ Clinic facility

Located in the central area of Fukuoka, not only the transportation is convenient, the living functions nearby are good, and the environment is good. The independent consultation room and treatment room in the hospital can make people feel at ease to receive treatment. The staff in the hospital are not only kind but also enthusiastic. If you have any questions about the treatment plan, you can discuss it with the doctor again, so as to facilitate cooperation with the current standard treatment.

Tenjin Cancer Clinic consultation room
God Treatment Room

​clinic address

〒810-0041 Fukuoka Prefecture

Floor 7, 2-6-39 Daimyo, Chuo-ku, Fukuoka City 

If you have any questions, please feel free to contact us through any of the methods below.

Name: *

Mailbox: *

Telephone: *

message:

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CONTACT US

TW contact only: +886-90-5563-717

JP For emergency contact: +81-80-4276-3930

 

​JP Tel / Fax:  +81-92 -984-3200

 

Mail: service@medicalsupporter.org

LINE@ ID: @medicalsupporter

 

LINE & WeChat & Skype: medicalsupporter

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