Ministry of Foreign Affairs of Japan Medical Visa Guarantee Agency No. B-66
Fukuoka Prefecture, Japan Travel service No. 35
Japanese Registration Support Organization No. 19-000303
Japan Medical Equipment Sales and Leasing
Medical Supporter
Accompanied with heart, medical care support in Japan
Cancer Gene Therapy - Gankyrin inhibitory RNA
Tenjin Cancer Clinic
The first step of cancer generation
Genetic Abnormality
human bodyThe genes in cells include "oncogenes" that produce cancer cells and "tumor suppressor genes" that suppress cancer cells that have already developed. In the case of healthy people, the balance of division and inhibition is maintained so that cancer cells do not continue to increase.
However, if the "tumor suppressor gene" is damaged due to diet, living environment, stress and other factors, the balance between division and inhibition is broken, and cells with abnormal genes (cancer cells) will divide endlessly.
◎About Gene Therapy
Cancer gene therapy is a method of treating cancer by suppressing genes in the body, promoting the normalization of abnormal genes, and suitable for each patient's gene therapy.
Cancer Treatment Without Hospitalization
Patients who come to the hospital regularly every 1 to 2 weeks are treated by drip, so this treatment is limited to patients who can come to the hospital regularly.
◎The process of cancer gene therapy to eliminate cancer
Characteristics of cancer cells: not prone to apoptosis
Induction: induces apoptosis through oncogene
Cancer cell characteristics: infinite proliferation
Induction: Blocks proliferative signals, inhibits cell division
Locking in cancer cell signatures
Induction: inhibition of cell proliferation through RNAi targets
◎Are there any genes that can be used in cancer gene therapy?
P53
Known as the patron saint of the genome, it is a tumor suppressor gene associated with "cancer cells". Promote apoptosis of cancerous cells.
P16
A tumor suppressor gene that delays and eliminates abnormal cell proliferation and prevents cancer.
Gankyrin inhibits RNA
Block the well-known tumor suppressor genes such as p53, p16, PTEN and RB, and target Gankyrin as the target RNA.
CDC6 suppresses RNA
Inhibits cell division that allows cancer cells to proliferate, creating an environment where other tumor suppressor genes can easily act.
PTEN
Tumor suppressor gene involved in cell proliferation and abnormal proliferation of cancer cells.
TRAIL
After binding to its receptor, it initiates apoptosis signal transmission, selectively induces tumor cell apoptosis, and has no obvious damage to normal tissue cells.
◎The relationship between Gankyrin and cancer
Gankyrin gene can block famous tumor suppressor genes such as p53, p16, PTEN and RB, and is related to tumor metastasis, invasion, proliferation and cell apoptosis. At present, most cancers contain Gankyrin gene. Through the Gankyrin inhibitory RNA gene therapy conducted by Tenshin Cancer Clinic, the expression of Gankyrin gene can be inhibited, so that the tumor suppressor gene in the body can restore its original function and accelerate the disappearance of cancer cells.
◎The relationship between TRAIL and cancer
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a kind of tumor necrosis factor (tumor necrosis factor, TNF). TRAIL binds to its receptor to initiate apoptosis signal transmission, selectively induces tumor cell apoptosis, and has no obvious damage to normal tissue cells. Combining drugs and cytokines can cooperate with TRAIL to induce tumor cell apoptosis. For most malignant tumors, TRAIL can significantly inhibit tumor growth and block cancer cell metastasis.
◎Treatment process
Gankyrin inhibits RNA
One course of treatment is six times, once every three weeks.
first visit
first
the second time
the third time
pre-treatment check
+
blood test
Drip + blood test (confirm tumor markers)
Drip + blood test (confirm tumor markers)
Drip + blood test (confirm tumor markers)
the fourth time
fifth time
the sixth time
Effect detection
Drip + blood test (confirm tumor markers)
Drip + blood test (confirm tumor markers)
Drip + blood test (confirm tumor markers)
Confirm tumor markers
TRAIL
One course of treatment is six times, once every three weeks.
first visit
first
the second time
the third time
pre-treatment check
+
blood test
Drip + blood test (confirm tumor markers)
Drip + blood test (confirm tumor markers)
Drip + blood test (confirm tumor markers)
the fourth time
fifth time
the sixth time
Effect detection
Drip + blood test (confirm tumor markers)
Drip + blood test (confirm tumor markers)
◎Clinic introduction
Drip + blood test (confirm tumor markers)
Confirm tumor markers