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Highly activated NK cell therapy

Ginza Phoenix Clinic

Highly activated NK cell therapy

NK cells are called "natural killer cells" and are a type of cell in the immune system. NK cells can directly recognize and attack virus-infected cells or cancer cells without being guided by antigen-presenting cells, and guide them to apoptosis.

Observed 3,625 residents aged 40 to 80 years old, divided them into three groups of high, medium and low NK cell activity and followed them for 11 years. It was found that men and women in the low NK cell activity group were more likely to develop cancer. The rate is also very high.


Recent research suggests that although cancer cells are always present, the natural immune system, such as NK cells, is thought to be able to identify and eliminate cancer cells. Therefore, when NK cell function declines, the inability to remove cancer cells may lead to their proliferation and formation of clinical tumors.

There is a protein called MHC class I on the cell surface of normal cells. MHC class I can present intracellular substances (antigens) outside the cell. Aged cells or cancer cells display specific antigens on the outside, and dendritic cells recognize these antigens and differentiate between normal cells and abnormal cells based on their types. When abnormal cells are recognized, dendritic cells instruct killer T cells, and these T cells carry the antigen to patrol the body. When T cells recognize the antigen of abnormal cells, they inject some proteins, such as perforin and granulin. , and stimulate cell membrane receptors and destroy abnormal cells through Fas ligand, etc. Therefore, cancer cells possessing MHC class I are excluded by this mechanism.


However, some cancer cells lack MHC class I expression. These cancer cells are not recognized by dendritic cells or killer T cells, so they survive. As a response to this situation, NK cells specifically attack cells lacking MHC class I. Therefore, when NK cell function decreases, this type of cancer cell is more likely to survive.

In addition, recent clinical studies have shown that some molecular targeted drugs (such as Herceptin, Perjeta, Rituxan, etc.) and NK cells can destroy cancer cells through cell-mediated immune defense mechanism (antibody-dependent cell-mediated cytotoxicity; ADCC). This mechanism allows NK cells to recognize cancer cells with molecularly targeted drugs, even if the NK cells cannot recognize these cells directly. These findings have attracted attention and are regarded as an example of the synergistic effect of the combined application of chemotherapy and immune cell therapy, becoming an important direction in the research of new cancer treatment strategies.

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NK cell activity and cancer incidence

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So far, I have introduced you to the relationship between NK cells and cancer cells. From a health perspective, maintaining the activity level of NK cells is related to preventing the progression of cancer.

As we age, NK cell activity levels decrease, making cancer more susceptible to cancer even after middle age. Even if young people are prone to colds, etc., it may indicate that the activity level of NK cells is low. Middle-aged and elderly people also need treatment to maintain high activity levels of NK cells.

NK cell therapy has been approved by the Japanese Ministry of Health, Labor and Welfare as a means of preventing cancer. It is recommended to regularly supplement highly active NK cells to increase their activity levels to eliminate developing cancer cells.

For cancer patients, increasing the activity of NK cells can also be used as a treatment. Since cancer patients will suffer from decreased NK cell function, it is also recommended to perform NK cell therapy while receiving other cancer treatments. However, patients receiving immune checkpoint inhibitors (such as Opdivo, Yervoy) cannot receive NK cell therapy at the same time. Immune checkpoint inhibitors have the effect of isolating cancer from the immune system, which also affects normal cells, so NK cells May attack normal cells.

Ginza Phoenix Clinic provides a variety of immune cell treatments depending on the patient's condition. For those interested in NK cell therapy, please feel free to inquire.

Highly activated NK cell therapy process

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  1. Phlebotomy: drawing blood from a patient

  2. Isolation: Separating lymphocytes from various cells in the blood

  3. Culture: Cultivate, proliferate, and activate NK cells

  4. Intravenous drip: injecting activated NK cells back into the body

  5. In vivo: Highly activated NK cells attack cancer cells, bacteria and viruses through antigens.

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After 3 weeks of culture, the number of NK cells is about 5 times that of 2 weeks of culture.

Other cell-related treatments: stem cell therapy

All cells inside the body, including cells that make up tissues and organs such as skin or blood, have a very short life span. In order for all tissues to be replaced smoothly and to maintain the good functioning of the body, new cells must be continuously replenished to replace cells that are about to undergo apoptosis. Cells with this ability are called "stem cells." A cell must have the following two abilities to be called a stem cell: first, the "differentiation ability", the ability to differentiate into epidermal cells, red blood cells, platelets and other various cells in the body; second, the "self-replication ability" , that is, the ability to replicate and divide into cells with the same functions as one's own.

Clinic introduction

Ginza Phoenix Clinic has obtained the second and third category certifications for regenerative medicine issued by the Ministry of Health, Labor and Welfare, and implements regenerative medicine in two major fields, namely "cancer immune cell therapy" and "stem cell therapy". The quality of immune cell therapy, including cell activity, is the most important. The Ginza Phoenix Clinic has a cell culture center that can provide the highest quality cell therapy. Ginza Phoenix Clinic has a team of physicians with extensive experience in regenerative medicine research and treatment. We will not give up on patient treatment, pay close attention to the patient's mood, and pursue various possibilities.

Clinic address

4-14-1 Sokanda, Chiyoda-ku, Tokyo, 6th floor, UDX Tower, Akihabara


01 Online consultation
Initial consulatio with medical consultnat via Line, Wechat, Email, or telephone.
Submit the form

02 Contract & agreement
We can provide English, Chinese, and Japanese version contract. Please comfirm and sign the contract then make the service payment

03 Translation 
We will based on the patient's medical records and translate to Japanese.

04 Confirmed by the hospital

Based on the patient information to choose the Japan medical institutions, then we will make appointments with doctor to know estimates.

05 Medical Visa
With the consent of the visiting medical institution. We can be the medical Visa Guarantee Agency for Japan

06 Travel arrangements
​ With the medical visa, you can prepare for the Japan medical treatment. Booking hotel and flight and customized travel itinerary.

07 VisitJapan for treatment
​Our professional medical consultants will accompany you throughout these process, and provide 24-hour emergency telephone and contact support services.

08 Follow up
We will contact you by telephone and mail to understand your condition after the treatment. Make sure next treatment can be smooth.

If you have any questions, please feel free to contact us.

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TW contact only: +886-90-5563-717

JP For emergency contact: +81-80-4276-3930


​JP Tel / Fax:  +81-92 -984-3200



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