immune checkpoint inhibitors

Immune cells themselves have the ability to attack and eliminate foreign substances in the body. In the early stages, when the number of cancer cells is low, immune cells are usually able to eliminate cancer cells. However, overactivation of immune cells can trigger an autoimmune response that attacks their own normal cells, so immune cells have molecules on their surface that suppress the immune response, called immune checkpoints, and some cancer cells have Molecules that act on immune checkpoints to prevent an immune response from occurring. The role of immune checkpoint inhibitors, therefore, is to block the function of these molecules, awakening the primordial ability of immune cells to attack cancer cells. Based on the results of multiple clinical trials, immune checkpoint inhibitors have been shown to be effective against a variety of cancers.

Helps facilitate the attack on cancer cells by releasing the immune suppression of T cells

When Opdivo enters the blood, it will connect with PD-1 on T cells, thereby blocking the combination with cancer cells and releasing the suppression of immune function. This action allows T cells to attack cancer cells without interference.

Side Effects Confirmed by Opdivo in Japan

• Interstitial lung disease (pneumonia, lung infiltrates, lung injury, etc.)

• Myasthenia gravis, myocarditis, myositis, rhabdomyolysis, or comorbidities of these conditions

• Colitis, enteritis, severe diarrhea

• type 1 diabetes

• Severe blood disorders (immune thrombocytopenic purpura, hemolytic anemia, agranulocytosis, etc.)

• Pulmonary insufficiency, liver dysfunction, hepatitis, sclerosing cholangitis

• Thyroid dysfunction

• pituitary dysfunction

• nervous disorder

• kidney dysfunction

• adrenal dysfunction

• encephalitis

• severe skin disorder

• venous thromboembolism

• hemophagocytosis syndromegroup

• tuberculosis

• pancreatitis

For these side effects, corresponding management and treatment should be carried out according to the specific conditions of the patients. if inOpdivoAny discomfort or side effects during use should be reported to a doctor immediately for proper treatment and treatment.

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Remarks: Taiwan has aboutOpdivoReferences for side effects​

Clinic introduction

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Dr.

HIROI NOBUYUKI